Effects of standardized Zataria multiflora extract and its major ingredient, Carvacrol, on Adriamycin-induced hepatotoxicity in rat

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Background and objectives: Cisplatin (CP), the chemotherapy drug, is used for the treatment of many types of cancer but causes hepatotoxicity. Zataria multiflora Boiss. (ZM), is a widely used herbal medicine with potent antioxidant properties. This study aimed to assess the protective effect of Zataria multiflora against cisplatin-induced hepatotoxicity. <strong...

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Paraquat-induced systemic inflammation and increased oxidative markers in rats improved by Zataria multiflora extract and carvacrol

Objective: Paraquat (PQ) is a herbicide which induces oxidative stress and inflammation. Anti-inflammatory and anti-oxidant effects were shown for Zataria multiflora (Z. multiflora) and carvacrol previously. The effects of Z. multiflora hydroalcoholic extract and carvacrol on systemic inflammation and oxidative stressinduced by inhaled PQ were examine...

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Carvacrol and Zataria multiflora influenced the PPARγ agonist effects on systemic inflammation and oxidative stress induced by inhaled paraquat in rat

Objective(s): The effects of PPAR-γ agonist alone and in combination with carvacrol and Zataria multiflora on inhaled paraquat (PQ) induced-systemic inflammation and oxidative stress were examined. Materials and Methods: Control group exposed to normal saline aerosol, one group exposed to 54 mg/m3 PQ aerosol and four groups exposed to PQ...

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The effect of Zataria multiflora Boiss hydroalcoholic extract and fractions in pentylenetetrazole-induced kindling in mice

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ژورنال

عنوان ژورنال: Biomedical Journal

سال: 2018

ISSN: 2319-4170

DOI: 10.1016/j.bj.2018.10.008